主题: Cell-instructive surfaces for smart implants主讲人: Bo Su地点: 松江校区四号学院楼3083室时间: 2017-10-26 14:30:00组织单位: 化学化工与生物工程学院
报告人简介：
Prof Bo Su is Professor of Biomedical Materials in the Bristol Dental School at theUniversity of Bristol, UK. He obtained his PhD in Materials from the University ofBirmingham, UK. His current research focuses on topographical modulation of cellsand bacteria. He has used a range of micro/nanopatterning techniques of titanium,ceramics and polymers for the development of cell-instructive surfaces. He is alsointerested in translational research in biomimetic and bio-inspired materials forvarious medical applications.
报告内容简介：
Cell-instructive surfaces that deter bacterial biofilm formation while encouragingtissue integration are highly desirable for application in medical implants where thereis often a competition between host tissue cell growth and bacterial colonisation attheir surfaces. It has been known that nanotopographical cue is a potent modulator toboth eukaryotic and prokaryotic cells under complex physiological conditions. Thequestion is whether we can utilise their differential responses for the rational design of‘smart’ medical implants that possess cell-instructive characteristics. In this talk, Iwill give an overview of our recent work on the effects of surface nanotopography onstem cell and bacterial response. Inspired by cicada and dragon fly wings whosesurfaces have been shown to display bactericidal nanotopographies, we haveproduced nanospikes on titanium and polymer substrates using a range ofnanopatterning techniques and investigated their influence to bacterialadhesion/viability and stem cell proliferation/differentiation. We have shown that it ispossible to elicit differential cell/bacterial responses using nanotopographical cue.The nanopatterned surfaces are selectively bactericidal against certain bacteria, whileinducing osteogenesis. These cell-instructive properties, together with the ease offabrication of these nanospikes, hold great promise for the fabrication of smartimplants used in orthopaedics and dentistry.
报告语言：英文