Fuzzy Discrete Event Systems: Theory and Its Application to HIV/AIDS Treatment
主题:    Fuzzy Discrete Event Systems: Theory and Its Application  to HIV/AIDS Treatment主讲人:   Hao Ying, Ph.D., IEEE Fellow, Professor地点:   松江校区2号学院楼226时间:   2015-10-13 09:30:37组织单位:   信息学院 数字化纺织服装技术教育部工程研究中心

报告人简介:

Dr. HaoYing is a professor at the Department of Electrical and Computer  Engineering,Wayne State University, USA. He has published one single-author book  entitled FuzzyControl and Modeling: Analytical Foundations and Applications  (IEEE Press,2000; foreword by Professor Lotfi A. Zadeh). He has recently  coauthored anotherbook titled Introduction to Type-2 Fuzzy Logic Control: Theory  and Applications(IEEE Press and John Wiley & Sons, Inc., 2014). In addition,  he haspublished over 100 peer-reviewed journal papers and 150 conference papers.  Hiswork has been widely cited - his Google Scholar h-index is 41. He is serving  asan Associate Editor or a Member of Editorial Board for eight  internationaljournals, including the IEEE Transactions on Fuzzy Systems. He  serves as amember of the Fuzzy Systems Technical Committee of the IEEE  ComputationalIntelligence Society and was elected to serve as a board member of  the NorthAmerican Fuzzy Information Processing Society for two terms. He served  asProgram Chair for three international conferences and also served as a  ProgramCommittee Member for over 70 international conferences. He is an IEEE  Fellow.


报告摘要:To effectivelyrepresent deterministic uncertainties and vagueness as  well as human subjectiveobservation and judgment encountered in many real-world  problems especiallythose in medicine, we recently originated a theory of fuzzy  discrete eventsystems (DES). We introduced fuzzy states and fuzzy event  transition andgeneralized conventional crisp DES to fuzzy DES. The largely  graph-based frameworkof the crisp DES was unsuitable for the expansion and we  thus reformulated itusing state vectors and event transition matrices which  could be extended to fuzzyvectors and matrices by allowing their elements to  take values in [0, 1]. We alsoextended optimal control of DES to fuzzy DES. The  new fuzzy DES theory isconsistent with the existing theory, both at conceptual  and computation levels,in that the former contains the latter as a special case  when the membershipgrades are either 0 or 1. We further developed the FDES  theory so that itpossessed self-learning capability.

We have applied the fuzzy DES theory todevelop an innovative software system  for medical treatment, specifically forthe first round of highly active  antiretroviral therapy of HIV/AIDS patients.The objective is to build such a  system whose treatment regimen choice for anygiven patient will match expert  AIDS physician’s selection to produce the (anticipated)optimal treatment  outcome. Preliminary retrospective evaluation of ourprototype system using  patients treated in our institution’s AIDS Clinical Center  demonstratesencouraging results when the system operates in either self-learning  mode ornon-learning mode. Our approach has the capabilities of generalizing,  learning,representing knowledge even in the face of weak consensus of domain  experts,and being readily upgradeable to new medical knowledge. These are  practically importantfeatures to medical applications in general, and HIV/AIDS  treatment inparticular, as national HIV/AIDS treatment guidelines are modified  severaltimes per year.

Thisresearch was supported in part by the National Institutes of Health  undergrantR21 EB001529-01A1, and by Wayne State University under aResearch  Enhancement Program grant.


主持人:丁永生教授


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